Programming is very important for learning to innovate and create eco-friendly solutions to global problems. Programming is also important in our day-to-day life to enhance the power of computers and internet. An important step towards learning innovative programming solutions is through Python programming which this book has at its core. Python is a popular object-oriented language used both for stand-alone programs and scripting applications in a variety of domains. This book presents a contemporary approach to programming with stress on principles of good programming, such as clarity, legibility and efficiency in program design. Thus, an interactive programming style has been emphasized/expressed throughout the book. The thoroughly revised Computer Science with Python for Class XII provides an in-depth understanding of the latest Computer Science (083) curriculum and strictly adheres to the guidelines laid down by the CBSE. The book deals with advanced concepts of Python Programming Language, Functions in Python, Exception Handling, Data File Handling, Data Structure, Relational Database Management System (SQL), Python-MySQL Connectivity and Computer Networks. However, an overview of Python Libraries has been included in the Appendices, which may be referred for project work. The text of the book has been presented in a student-friendly and easy-to-comprehend language. Each chapter provides tested, debugged and error-free codes with screenshots. With easy-to-understand examples, practical implementations, problem-solving and case-based questions, students will learn how to design the logic of programs and implement those programs using Python. Based on the CBSE curriculum, the book has been divided into three units: Unit I: Computational Thinking and Programming-2 – Chapters 1 – 5 This unit contains five chapters covering a review of Python studied in Class XI, concept of functions and modules in Python, Exception Handling using try-except-finally blocks, Text, B